| Abstrakt: |
A study conducted by researchers at Washington University in St. Louis, Missouri, has shed light on the mechanisms underlying CD4+ T cell depletion in HIV and SIV infections. The researchers found that the CARD8 inflammasome is activated by the viral protease in HIV, leading to the death of quiescent cells without productive infection. T cell activation, on the other hand, increases susceptibility to infection. The study also discovered loss-of-function mutations in CARD8 in "natural hosts," which may explain the non-pathogenic nature of these infections. The findings suggest that CARD8 drives CD4+ T cell depletion in pathogenic HIV/SIV infections. [Extracted from the article] |
