Academy of Military Medical Sciences Researchers Describe Research in Salmonella typhimurium (The Trimeric Autotransporter Adhesin SadA from Salmonella spp. as a Novel Bacterial Surface Display System).

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Zdroj: Vaccine Weekly; 5/17/2024, p220-220, 1p
Abstrakt: A study conducted by researchers at the Academy of Military Medical Sciences in Beijing, China, explores the use of Salmonella typhimurium as a bacterial surface display system for vaccine delivery and peptide library screening. The researchers focused on the SadA protein, which promotes biofilm formation and host cell adherence. They found that SadA can display heterologous proteins on the surface of S. typhimurium, and this system could potentially be used for the development of attenuated bacterial vaccines. The study provides valuable insights into the potential applications of bacterial surface display platforms in vaccine research. [Extracted from the article]
Databáze: Complementary Index