| Autor: |
Kaiye Wang, Xiaohan Liu, Yuting Jia, Limeng Pan, Mingwan Shi, Wei Pan, Na Li, Bo Tang |
| Předmět: |
|
| Zdroj: |
Chemical Communications; 5/4/2024, Vol. 60 Issue 36, p4773-4776, 4p |
| Abstrakt: |
This article explores the development of a small-molecule Fenton reagent for chemodynamic therapy (CDT) in cancer treatment. The researchers designed a molecule that combines a Fenton reagent with a carbonic anhydrase inhibitor to regulate intracellular acidosis. They synthesized nanoparticles containing this molecule and demonstrated its effectiveness in inducing cellular acidosis and promoting tumor cell damage. The reagent, called FSC NPs, was tested on tumor cells in vitro and in vivo using mice, showing promising results in inhibiting tumor growth and triggering ferroptosis. This study suggests that FSC NPs could be a highly effective approach for cancer treatment. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
