Blastoid Variant Mantle Cell Lymphoma with Amplified IGH/CCND1 Fusion: A Unique Case and Current Literature Review.
| Autor: | Goktas, Emine, Sanal, Sumeyye, Esen, Haci Hasan, Tekinalp, Atakan |
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| Předmět: |
THERAPEUTIC use of antineoplastic agents
BIOPSY BLADDER tumors NON-Hodgkin's lymphoma PAPILLARY carcinoma COMPUTED tomography ANTINEOPLASTIC agents TUMOR lysis syndrome CHROMOSOME abnormalities RITUXIMAB BLOOD cell count TREATMENT effectiveness IMMUNOHISTOCHEMISTRY FLUORESCENCE in situ hybridization ONCOLOGISTS MEDICAL referrals COLONOSCOPY GENETIC testing DISEASE complications |
| Zdroj: | Medical Bulletin of Haseki / Haseki Tip Bulteni; Mar2024, Vol. 62 Issue 2, p124-127, 4p |
| Abstrakt: | Mantle cell lymphoma (MCL) is a subtype of mature B-cell non-Hodgkin lymphoma (NHL). Most cases exhibit CCDN1/IGH translocation; however, reports indicate that amplification of the fusion gene is extremely rare. A 72-year-old male patient diagnosed with an MCL blastoid variant was referred to us. Amplified CCDN1(11q13)/IGH(14q32.3) fusion genes were observed in 75% of the interphase nuclei of the patient. We present the first case of blastoid variant MCL with multiple IGH/CCND1 fusion signals by interphase fluorescence in situ hybridization. Our patient exhibited an aggressive course and passed away on the second day of treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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