| Autor: |
Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E, Palpant, Nathan J |
| Předmět: |
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| Zdroj: |
European Heart Journal; 5/1/2024, Vol. 45 Issue 17, p1571-1574, 4p |
| Abstrakt: |
The article discusses the potential benefits of blocking acid-sensing ion channel 1a (ASIC1a) in reducing myocardial injury in rodent models of myocardial infarction (MI). The study found that administering the ASIC1a inhibitor, Hi1a, before or after the onset of ischemia reduced infarct size and prevented cardiac dysfunction associated with MI. Hi1a was also found to have minimal adverse effects on heart rhythm and blood pressure. The findings suggest that Hi1a could be a promising drug candidate for treating severe ischemic injury in patients with MI. Further research is needed to evaluate Hi1a in larger animal models and in co-morbid conditions to assess its potential for clinical translation. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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