| Abstrakt: |
Researchers from Northwestern Polytechnic University in Xi'an, China have developed a responsive coating for titanium orthopedic implants that can enhance osseointegration and eliminate bacterial infections. The coating consists of TiO2 nanotubes (TNT) that serve as reservoirs for antibiotics, and a macromolecular layer that releases therapeutic gas hydrogen sulfide (H2S) and antibiotics on demand. In vitro experiments showed significant antibacterial activity against both Gram-negative and Gram-positive bacteria, and in a rat femoral bone defect model, the coating effectively suppressed implant-associated infection, reduced inflammation, and promoted osseointegration. This research has been peer-reviewed and published in Advanced Healthcare Materials. [Extracted from the article] |
