| Abstrakt: |
A recent study conducted at the University of California San Diego (UCSD) has provided new insights into Citrobacter rodentium, a mouse pathogen used as a model organism for studying infections caused by human pathogens. The study found that interleukin (IL)-22, a cytokine secreted by innate lymphoid cells and T cells, plays a crucial role in promoting mucosal barrier function during C. rodentium infection. The research also investigated the specific antimicrobial proteins modulated by IL-22 and found that multiple antimicrobial responses may contribute to host resistance against C. rodentium infection. These findings suggest that IL-22 and other IL-22-regulated processes are important for host defense against attaching and effacing pathogens. [Extracted from the article] |
