Susceptibility of optic nerve head in children with posture-related elevation of intraocular pressure.

Autor: Lüke, Jan Niklas, Gietzelt, Caroline, Enders, Philip, Dietlein, Johanna, Lappa, Alexandra, Lüke, Vincent, Widder, Randolf Alexander, Dietlein, Thomas S.
Zdroj: International Ophthalmology; 2024, Vol. 44 Issue 1, p1-7, 7p
Abstrakt: Background/Aims: This work aimed to investigate changes in optic nerve head (ONH) morphometry based on Bruch membrane opening in children with extensive nocturnal intraocular pressure (IOP) elevations. Methods: The course of Bruch membrane opening-based optic nerve head (ONH) morphometry was analysed in thirty-two patients younger than 18 years with evaluable SD-OCT examinations of the ONH and nocturnal posture-dependent IOP elevation above 25 mmHg. Longitudinal changes in neuroretinal rim tissue, as measured by Bruch Membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness, were assessed. Results: One year after the 24 h IOP measurement, global BMO-MRW (− 1.61 ± 16.8 µm, n.s.; p = 0.611) and RNFL (+ 0.64 ± 3.17 µm; n.s.; p = 0.292) measurements were not significantly different from the baseline. No significant BMO-MRW reduction (− 3.91 ± 24.3 µm; n.s. p = 0.458) or deviation in RNFL thickness (+ 1.10 ± 3.52 µm) was observed at the four-year follow-up. Absolute IOP values measured in the supine position did not correlate with changes in global BMO-MRW or RNFL thickness. Conclusion: Posture-dependent IOP elevations do not seem to influence retinal nerve fibre layer thickness or Bruch membrane opening-based morphometric data in childhood. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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