| Autor: |
Jihye Kim, Bury, Matthew I., Kyeongha Kwon, Jae-Young Yoo, Halstead, Nadia V., Hee-Sup Shin, Shupeng Li, Sang Min Won, Min-Ho Seo, Yunyun Wu, Do Yun Park, Kini, Mitali, Jean Won Kwak, Madhvapathy, Surabhi R., Ciatti, Joanna L., Jae Hee Lee, Suyeon Kim, Hanjun Ryu, Yamagishi, Kento, Hong-Joon Yoon |
| Předmět: |
|
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 4/2/2024, Vol. 121 Issue 14, p1-11, 46p |
| Abstrakt: |
Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
