| Abstrakt: |
A recent study conducted by researchers at the ACECR Institute of Higher Education in Isfahan, Iran, has explored the role of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) in the development of polycystic ovary syndrome (PCOS). The study analyzed RNA-seq, microarray, and miRNA-seq data from granulosa cells and blood samples of PCOS patients. The researchers identified dysregulation in the expression of XIST, as well as 1131 mRNAs and 30 miRNAs, in the GCs of PCOS patients. They also constructed a ceRNA network involving XIST, miRNAs, and mRNAs, with ETS2 identified as a pivotal gene. The study further identified two potential compounds, methotrexate/folate and threonine, for PCOS management. These findings provide new insights into the molecular mechanisms, diagnosis, and potential therapeutic interventions for PCOS. [Extracted from the article] |
