| Abstrakt: |
Researchers from King's College London have developed a new method for monitoring the activity of matrix metalloproteinases (MMPs) in real-time within tissue-like 3D microenvironments. MMPs play a central role in matrix remodeling, but their regulation of cell and tissue dynamics is not well understood. The researchers incorporated a FRET sensor of MMP activity into synthetic hydrogels that mimic the native extracellular matrix, allowing for high-resolution, quantitative, and in situ monitoring of MMP activity. This versatile platform has the potential to provide insights into cancer metastasis, development, and tissue repair. [Extracted from the article] |
