| Autor: |
Souza, Aline de, Scarim, Cauê Benito, Cotrim, Paulo Cesar, Junior, Fernando Barbosa, Rocha, Bruno Alves, Calixto, Leandro Augusto, Correia, Cristiano Jesus, de Barros Araújo, Gabriel Lima, Löbenberg, Raimar, Bou-Chacra, Nádia Araci, Breithaupt-Faloppa, Ana Cristina |
| Zdroj: |
Nanomedicine; Feb2024, Vol. 19 Issue 4, p293-301, 9p |
| Abstrakt: |
Background: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 μg/ml, respectively. After chylomicron blocking, NFOH was not detected. Conclusion: Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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