| Autor: |
Correa Marrero, Miguel, Capdevielle, Sylvain, Huang, Weijie, Al‐Subhi, Ali M., Busscher, Marco, Busscher‐Lange, Jacqueline, van der Wal, Froukje, de Ridder, Dick, van Dijk, Aalt D. J., Hogenhout, Saskia A., Immink, Richard G. H. |
| Zdroj: |
Plant Journal; Feb2024, Vol. 117 Issue 4, p1281-1297, 17p |
| Abstrakt: |
SUMMARY: Phytoplasmas are pathogenic bacteria that reprogram plant host development for their own benefit. Previous studies have characterized a few different phytoplasma effector proteins that destabilize specific plant transcription factors. However, these are only a small fraction of the potential effectors used by phytoplasmas; therefore, the molecular mechanisms through which phytoplasmas modulate their hosts require further investigation. To obtain further insights into the phytoplasma infection mechanisms, we generated a protein–protein interaction network between a broad set of phytoplasma effectors and a large, unbiased collection of Arabidopsis thaliana transcription factors and transcriptional regulators. We found widespread, but specific, interactions between phytoplasma effectors and host transcription factors, especially those related to host developmental processes. In particular, many unrelated effectors target specific sets of TCP transcription factors, which regulate plant development and immunity. Comparison with other host‐pathogen protein interaction networks shows that phytoplasma effectors have unusual targets, indicating that phytoplasmas have evolved a unique and unusual infection strategy. This study contributes a rich and solid data source that guides further investigations of the functions of individual effectors, as demonstrated for some herein. Moreover, the dataset provides insights into the underlying molecular mechanisms of phytoplasma infection. Significance Statement: This work shows that the effectors of phytoplasma, a globally economically important bacterial plant pathogen, have pervasive interactions with development‐related host transcription factors, providing a way to take over plant growth and development in favor of the pathogen and its insect vector. The obtained comprehensive protein interaction network and a showcase of the potential biological consequences of a selected effector advance our understanding of phytoplasma‐host interactions and provide guidance for further study. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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