Reaction of 1,2,4-Triazine-5-carbonitriles with 5-[(2-Hydroxyethyl)sulfanyl]- and 5-{[2-(2-Hydroxyethoxy)-ethyl]sulfanyl}-3-amino-1,2,4-triazoles1.

Autor: Krinochkin, A. P., Ladin, E. D., Shtaitz, Ya. K., Kudryashova, E. A., Kopchuk, D. S., Gorbunov, E. B., Shafran, Yu. M., Zyryanov, G. V., Rusinov, V. L.
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Zdroj: Russian Journal of Organic Chemistry; Nov2023, Vol. 59 Issue 11, p1998-2002, 5p
Abstrakt: The solvent-free reaction of 1,2,4-triazine-5-carbonitriles with newly synthesized 5-[(2-hydroxyethyl)sulfanyl]- and 5-{[2-(2-hydroxyethoxy)ethyl]sulfanyl}-3-amino-1,2,4-triazoles under heating was studied. It was shown that in the case when the C5 atom of the 1,2,4-triazole ring bears hydroxy(ethoxy)ethylsulfanyl substituents, 5-amino-1,2,4-triazines are formed as the main reaction products, while the ipso-substitution products of the C5-cyano group of the substituted 1,2,4-triazole ring were isolated only as by-products. With a 1,2,4-triazole with a monoethylene glycol fragment at the C5 position, a complex mixture of products was formed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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