Long-term response to sequential anti-HER2 therapies including trastuzumabderuxtecan in a patient with HER2-positive metastatic breast cancer with leptomeningeal metastases: a case report and review of the literature.

Autor:	de Bernardi, Axel, Bachelot, Thomas, Larrouquère, Louis
Předmět:	METASTATIC breast cancer HER2 positive breast cancer LITERATURE reviews MENINGEAL cancer BREAST cancer CANCER patients HORMONE receptor positive breast cancer
Zdroj:	Frontiers in Oncology; 2024, p1-11, 11p
Abstrakt:	The incidence of leptomeningeal metastases (LM) is increasing among breast cancer patients, but their prognosis remains dismal. Many therapeutic options are now available to treat HER2-positive (HER2+) metastatic breast cancer (MBC) involving the central nervous system (CNS). This case report illustrates a longlasting response of more than 2 years in a patient with HER2+ MBC with LM after sequential administration of systemic and intrathecal (IT) anti-HER2 therapies and highlights that an appropriate treatment of HER2+ LM can result in durable survival. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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