| Autor: |
Krutz, Matthew, Acharya, Pawan, Elliott, Jacey, Zhao, Daniel, Mhawej, Rachad, Queimado, Lurdes |
| Zdroj: |
Otolaryngology-Head & Neck Surgery; Feb2024, Vol. 170 Issue 2, p438-446, 9p |
| Abstrakt: |
Objective: To determine the effect of tobacco cessation following laryngeal cancer diagnosis on response to first‐line therapy, laryngectomy‐free survival, and overall survival in patients who were current smokers at the time of diagnosis. Study Design: Retrospective, case‐control study. Setting: OU Stephenson Cancer Center, National Cancer Institute‐Designated Cancer Center. Methods: We included 140 patients diagnosed with laryngeal squamous cell carcinoma, who were current smokers at the time of diagnosis, and were treated with first‐line definitive radiation or chemo/radiation with the intent to cure. The association between patient characteristics and treatment response was assessed using the χ2 test and logistic regression analysis. Survival outcomes were analyzed using Kaplan‐Meier methods and Cox proportional‐hazards models. Results: Of the 140 current smokers, 61 patients (45%) quit smoking prior to treatment initiation. In adjusted logistic regression analysis, quitters had 3.7 times higher odds of achieving a complete response to first‐line therapy than active smokers (odds ratio: 3.694 [1.575‐8.661]; P =.003). In the adjusted Cox proportional‐hazards model, quitters were 54% less likely to require salvage laryngectomy within 7 years of diagnosis than active smokers (hazard ratio: 0.456 [0.246‐0.848]; P =.013). Quitters had a statistically significant increase in 7‐year overall survival compared to active smokers (P =.02). Conclusion: This is the first study to show that in newly diagnosed laryngeal cancer patients who are current smokers at the time of diagnosis, tobacco cessation significantly increases therapy response, laryngectomy‐free survival, and overall survival. These data stress the importance of systematically incorporating tobacco cessation programs into laryngeal cancer treatment plans. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text