| Autor: |
Safranek, Conrad W., Wilkins, Sarah G., Shah, Rema, Mehra, Saral |
| Zdroj: |
Otolaryngology-Head & Neck Surgery; Feb2024, Vol. 170 Issue 2, p627-629, 3p |
| Abstrakt: |
With the American Joint Committee on Cancer (AJCC) 8th edition staging guidelines update, human papillomavirus‐positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) is now staged separately from its HPV‐negative counterpart, preventing meaningful comparison of cases staged with the 7th versus 8th edition criteria. Manual restaging is time‐consuming and error‐prone, hindering multiyear analyses for HPV+ OPSCC. We developed an automated computational tool for re‐classifying HPV+ OPSCC pathological and clinical tumor staging from AJCC 7th to 8th edition. The tool is designed to handle large data sets, ensuring comprehensive and accurate analysis of historic HPV+ OPSCC data. Validated against institutional and National Cancer Database data sets, the algorithm achieved accuracies of 100% (95% confidence interval [CI] 98.8%‐100%) and 93.4% (95% CI 93.1%‐93.7%), successfully restaging 326/326 and 26,505/28,374 cases, respectively. With its open‐source design, this computational tool can enhance future HPV+ OPSCC research and inspire similar tools for other cancer types and subsequent AJCC editions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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