Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.

Autor: Vogel, Ulla, Saber, Anne T., Jacobsen, Nicklas R., Danielsen, Pernille H., Hougaard, Karin S., Hadrup, Niels
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Zdroj: Archives of Toxicology; Feb2024, Vol. 98 Issue 2, p567-569, 3p
Abstrakt: A recent article in the Archives of Toxicology by Christian Monsé and colleagues comments on the suggested occupational exposure limit for zinc oxide (ZnO) made by the National Research Centre for the Working Environment (NFA) in Denmark. The authors argue that a higher limit for ZnO could be justified based on their controlled human exposure study, which reproduced the dose-dependent ZnO-induced acute phase response observed in mice. They suggest that the No Observed Adverse Effect Concentration (NOAEC) for an 8-hour working day should be 0.25 mg/m3. The authors also discuss the potential health risks associated with ZnO exposure, particularly in relation to cardiovascular disease. They disagree with Monsé et al.'s argument that the ZnO-induced acute phase response is substance-specific, citing evidence of similar responses to soluble and insoluble particles in both humans and mice. The authors also highlight the importance of considering lifestyle factors and inter-individual variation when assessing the health effects of ZnO exposure. Overall, they suggest that a lower exposure limit for ZnO may be warranted. [Extracted from the article]
Databáze: Complementary Index
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