| Autor: |
Kennett, Alice, Epple, Sven, van der Valk, Gabriella, Georgiou, Irene, Gout, Evelyne, Vivεave;s, Romain R., Russell, Angela J. |
| Předmět: |
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| Zdroj: |
Chemical Communications; 1/14/2024, Vol. 60 Issue 4, p436-439, 4p |
| Abstrakt: |
Sulf-2 has been identified as a putative target for anticancer therapies. Here we report the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S). Trisulfated disaccharide inhibitor IdoA(2S)-GlcNS(6Sulfamate) demonstrated potent Sulf-2 inhibition. The IC50 value was determined to be 39.8 μM ± 18.3, which is comparable to a tetrasaccharide inhibitor of HSulf-1 reported in the literature. We propose that the disaccharide IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of the Sulfs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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