| Abstrakt: |
A recent study conducted by researchers at Gansu University of Chinese Medicine in China explored the therapeutic effect of naringin (NAR) on bacterial-induced lung inflammation caused by Klebsiella pneumoniae (Kpn) infection. The study found that mice infected with Kpn exhibited increased white blood cells and neutrophils, as well as severe lung injury and elevated expression of inflammatory cytokines. However, treatment with NAR decreased the protein expression of NLRP3, alleviated lung inflammation, and reduced lung injury in mice. The study suggests that NAR could protect against Kpn-induced pneumonia by inhibiting the overactivation of the NLRP3 inflammasome signaling pathway. This research provides a theoretical basis for the development of NAR as an anti-inflammatory adjuvant. [Extracted from the article] |
