| Autor: |
Huynh, Julia, Leiter, Ulrike, Garbe, Claus, Shiderova, Galina, Walter, Vincent, Eigentler, Thomas, Scheu, Alexander, Häfner, Hans‐Martin, Schnabl, Saskia Maria |
| Předmět: |
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| Zdroj: |
Journal of the European Academy of Dermatology & Venereology; Jan2024, Vol. 38 Issue 1, p84-92, 9p |
| Abstrakt: |
Background: Lentigo maligna melanoma is mainly localized in the head and neck region in elderly patients. Due to its slow horizontal growth, it has a good prognosis compared to other melanoma subtypes, but specific data are rare. Objectives: The aim of this study was to investigate sentinel lymph node biopsy in lentigo maligna melanoma under local anaesthesia and to discuss the benefit. Methods: Investigation of patients with lentigo maligna melanoma and tumour thickness ≥1 mm treated at the Department of Dermatology, University Medical Centre Tuebingen, between January 2008 and October 2019. Results: In total, 204 patients (126 SLNB, 78 non‐SLNB) with a median age of 75.7 years (SLNB: 73.3 years, non‐SLNB: 79.7 years) could be included. Sixteen of 126 (12.7%) sentinel lymph nodes were positive. Five‐year overall survival was 87.9% (88.5% SLNB; 87.4% non‐SLNB) and 5‐year distant metastasis‐free survival was 85.8% (85.4% SLNB; 86.7% non‐SLNB). There was no significant difference for distant metastasis‐free survival (p = 0.861) and overall survival (p = 0.247) between patients with and without sentinel lymph node biopsy. Conclusions: Sentinel lymph node biopsy in lentigo maligna melanoma under local anaesthesia is a safe and simple method, even in very old patients. However, LMM has a very good 5‐year overall survival. In high‐risk patients with high tumour thickness and/or ulceration, adjuvant immunotherapy can now be offered without the need to perform this procedure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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