| Abstrakt: |
A recent study conducted by Nankai University in Tianjin, China, explores the mechanisms by which Salmonella enterica serovar Typhimurium (S. Typhimurium) survives and replicates in host cells. The researchers found that S. Typhimurium upregulates a phosphate transporter called PIT1, which transports phosphate from Salmonella-containing vacuoles (SCVs) into the cytosol, resulting in phosphate starvation within the SCVs. This process is mediated by the TLR4-MyD88-NF-kB signaling pathway. The study provides new insights into the host-pathogen interactions of S. Typhimurium and may contribute to the development of therapeutics to combat bacterial infections. [Extracted from the article] |
