| Abstrakt: |
A study conducted at Harbin Medical University in China has found that a compound called dendrocandin U, derived from Dendrobium officinale Kimura et Migo, has significant anti-inflammatory effects. The researchers isolated and identified six compounds from Dendrobium officinale, including dendrocandin U, dendronbibisline B, and (-)-syringaresinol, which exhibited anti-inflammatory properties by inhibiting nitric oxide secretion and reducing inflammatory morphological changes in macrophages. The study also revealed that dendrocandin U inhibits M1 polarization by suppressing the toll-like receptor 4 (TLR4)/recombinant myeloid differentiation factor 88 (MyD88)/nuclear factor kappa B (NF-kappa B) signaling pathway. These findings provide a basis for further research on the development of anti-inflammatory drugs. [Extracted from the article] |
