Persistent Organic Pollutant Exposure and Thyroid Function among 12-Year-Old Children.
| Autor: | Tillaut, Hélène, Monfort, Christine, Giton, Frank, Warembourg, Charline, Rouget, Florence, Cordier, Sylvaine, Lainé, Fabrice, Gaudreau, Eric, Garlantézec, Ronan, Saint-Amour, Dave, Chevrier, Cécile |
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| Zdroj: | Neuroendocrinology; 2023, Vol. 113 Issue 12, p1232-1247, 16p |
| Abstrakt: | Introduction: Polychlorobiphenyls (PCBs), organochlorine pesticides (OCPs), and per- and polyfluoroalkyl substances (PFASs) are persistent organic pollutants (POPs) having numerous toxicological properties, including thyroid endocrine disruption. Our aim was to assess the impact of POPs on thyroid hormones among 12-year-old children, while taking puberty into consideration. Methods: Exposure to 7 PCBs, 4 OCPs, and 6 PFASs (in µg/L), and free tri-iodothyronine (fT3, pg/mL), free thyroxine (fT4, ng/dL), and thyroid-stimulating hormones (TSH, mIU/L) were assessed through blood-serum measurements at age 12 years in 249 boys and 227 girls of the PELAGIE mother-child cohort (France). Pubertal status was clinically rated using the Tanner stages. For each POP, associations were estimated using linear regression, adjusted for potential confounders. Results: Among boys, hexachlorobenzene and perfluorodecanoic acid were associated with decreased fT3 (log-scale; β [95% confidence interval] = -0.07 [−0.12,−0.02] and β = −0.03 [−0.06,−0.00], respectively). Intermediate levels of perfluorohexanesulfonic acid (PFHxS) and PCB180 were associated, respectively, with increased and decreased fT4. After stratification on pubertal status, PCBs and OCPs were associated with decreased TSH only in the more advanced Tanner stages (3–5) and with decreased fT3 among early Tanner stages (1–2). Among girls, PFHxS was associated with decreased TSH (log-scale; β = −0.15 [−0.29,-0.00]), and perfluorooctanoic acid was associated with decreased fT3 (β |
| Databáze: | Complementary Index |
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