The Effect of the Antioxidant System "Resveratrol – Iron Sulfonitrosyl Complex Sodium-μ2-Dithiosulphate-Tetranitrosyl Diferrate Tetrahydrate" on the Mitochondria of Pea Germ Epicotyls in vitro.

Autor: Gerasimov, N. Yu., Nevrova, O. V., Zhigacheva, I. V., Generozova, I. P., Goloshchapov, A. N.
Zdroj: Biophysics; Aug2023, Vol. 68 Issue 4, p525-530, 6p
Abstrakt: The interaction of antioxidants, plant polyphenol resveratrol and nitric oxide donor, sulfur nitrosyl iron complex with thiosulfate Na2[Fe2(S2O3)2(NO)4]2 · 4H2O (TNIC-thio), and their combined action on the mitochondria of epicotyls of pea seedlings in vitro were studied. The antioxidant activity of resveratrol at a concentration of 10–6 M partially compensated for the toxic effect of TNIC-thio at high concentrations, which was most likely due to the manifestation of the pro-oxidant properties of high concentrations of the nitric oxide donor. The effect of resveratrol at concentrations of 10–6 and 10–8 M on the membranes of mitochondria isolated from the epicotyls of pea seedlings in the presence of 10–8 M TNIC-thio led to a violation of the regulation system of lipid peroxidation of membranes, which caused antioxidant stress. The effect of resveratrol at a dose of 2 × 10–5 M was of a dual nature and practically did not affect the structural state of mitochondrial membranes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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