| Abstrakt: |
Aim: To identify genomic variants associated with hypo-response to COS in patients with repeated intrauterine insemination (IUI) and/or in vitro fertilization (IVF) failures and devise appropriate management strategies. Materials and methods: Twelve patients with a history of IUI/IVF failures were included in the study. Next generation sequencing (NGS) based genomic analysis on peripheral blood, designed for Indian population was performed to identify risk genotypes. Multiple causative and susceptibility genotypes associated with oogenesis, fertilization, implantation failure, pregnancy loss, premature ovarian insufficiency, oocyte quality, response to COS, and pharmacogenomic correlations were part of the genomic panel. Results: A total of six variants were reported with poor or slow response to controlled ovarian stimulation in AMH, AMHR2, ESR1, FSHR, and LHCGR genes. In two cases, thrombophilia related variants in VEGFA and MTRR genes were also identified. Based on the genotypes identified with ovarian response correlations, stimulation protocols were modified and better outcome was recorded. Conclusion: We demonstrate identification of hypo-responders and customization of controlled ovarian stimulation protocols based on genomic analysis combined with clinical parameters leading to reduction in number of cycles and improving outcome or reproductive success. [ABSTRACT FROM AUTHOR] |
