Acetyl-11-Keto-Beta-Boswellic Acid Activates the Nrf2/HO-1 Signaling Pathway in Schwann Cells to Reduce Oxidative Stress and Promote Sciatic Nerve Injury Repair.
Autor: | Zhou, Chong, Wang, Yao, Zhang, Qiyuan, Zhou, Guanghu, Ma, Xianglin, Jiang, Xiaowen, Yu, Wenhui |
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Předmět: |
IN vitro studies
SCIATIC nerve ANIMAL experimentation FUNCTIONAL status CONVALESCENCE PERIPHERAL nervous system ANTIOXIDANTS APOPTOSIS CELLULAR signal transduction OXIDATIVE stress RATS GENE expression RESEARCH funding TRANSCRIPTION factors PLANT extracts REACTIVE oxygen species NEUROGLIA NERVOUS system regeneration LIPID peroxidation (Biology) |
Zdroj: | Planta Medica; Dec2023, Vol. 89 Issue 15, p1468-1482, 15p |
Abstrakt: | Boswellia is a traditional medicine for bruises and injuries. Its main active ingredient, acetyl-11-keto-beta-boswellic acid, has antioxidant and antiapoptotic effects. In this experiment, we used Sprague-Dawley rats to make a sciatic nerve injury model to detect the transcription factor NF-E2-related factor 2/heme oxygenase 1 signaling pathway and apoptosis, combined with clinical indicators, for testing whether acetyl-11-keto-beta-boswellic acid can reduce oxidative stress and promote sciatic nerve repair. Our results showed that acetyl-11-keto-beta-boswellic acid administration promoted myelin regeneration and functional recovery in the rat sciatic nerve, reduced lipid peroxidation levels, upregulated the expression of various antioxidant enzymes and enhanced enzyme activity, decreased the expression levels of apoptosis-related proteins, and promoted nuclear translocation of the transcription factor NF-E2-related factor 2 protein. In vitro studies revealed that acetyl-11-keto-beta-boswellic acid reduced H |
Databáze: | Complementary Index |
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