| Autor: |
Mediconda, Shivaratna, Abidullah, Mohammed, Velidandla, Surekha |
| Předmět: |
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| Zdroj: |
Journal of Oral & Maxillofacial Pathology (0973029X); Jul-Sep2023, Vol. 27 Issue 3, following p561-561, 9p |
| Abstrakt: |
Aim: To evaluate the role of lactate dehydrogenase (LDH) as a biomarker in the progression of potentially malignant disorders in smokers and gutkha chewers. Material and Methods: The total of 70 individuals having the habit of chewing gutkha and smoking were selected for the study and divided into four groups. Group 1: 20 individuals having the habit of smoking, Group 2: 20 individuals having the habit of chewing gutkha, Group 3: 20 individuals having the habit of smoking and gutkha chewing, and Group 4: 10 healthy individuals. Results: In the present study showed that unstimulated whole saliva from group 1, group 2, and group 3 individuals, there was a significant decrease in isoenzymes LDH-1 and LDH-2 and there was no effect on LDH-3 isoenzyme. In the present study, there is a significant increase in salivary isoenzyme LDH-4. The result indicated that there is an effect of carcinogen (tobacco)-enhanced activity on salivary LDH. The present study showed 70 volunteers reported a statistical significant correlation among the groups. The individuals with habit of smoking and gutkha chewing showed P value <.001 with a significant increase in the isoenzyme LDH-4. A significant increase in the buccal micronuclei of exfoliated cells in the oral mucosal cells of smokers and gutkha chewers. This shows a positive relationship between LDH isoenzymes and the individuals with the smoking and chewing of tobacco. Conclusion: There was a significant correlation between the levels of salivary LDH isoenzymes and cytomorphometric analysis of oral epithelium in smokers and gutkha chewers. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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