| Autor: |
Yoshimatsu, Masako, Kawashita, Yumiko, Soutome, Sakiko, Murata, Maho, Sawayama, Yasushi, Kurogi, Tadafumi, Nakao, Noriko, Miyazaki, Yasushi, Umeda, Masahiro, Ukai, Takashi |
| Zdroj: |
Supportive Care in Cancer; Dec2023, Vol. 31 Issue 12, p1-10, 10p |
| Abstrakt: |
Purpose: Oral mucositis (OM) is a side effect associated with cancer treatment. Hangeshashinto (HST), a Kampo medicine, was originally prescribed to treat diarrhea, gastritis, and stomatitis. Several reports have described the effects of HST for OM induced by chemotherapy in patients with gastric or colorectal cancer. In this study, the effects of HST for prevention of OM were investigated in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods: Thirty patients scheduled to receive allogeneic grafts were enrolled from July 2020 to December 2021. They were randomly assigned to two groups and instructed to wash their mouth using HST dissolved in saline solution or using only saline solution three times a day. The observation period was from the initiation date of the conditioning regimen to the date of engraftment, and the end point was the incidence of OM. Results: Eighteen patients developed OM, the most severe of which was Grade (G)3. There was no significant difference in the incidence of OM between the HST group and the control group. However, a negative correlation tended to be observed between the duration using HST use and the duration of OM (G2–3: P = 0.027, G3: P = 0.047). Conclusions: The present study demonstrated that HST use did not clearly inhibit onset of OM but showed a tendency to inhibit OM exacerbation. However, further studies are necessary to fully understand the effects of HST on OM in patients undergoing HSCT. Trial registration: This study was registered in the Japan Registry of Clinical Trials on 7 May 2020 (jRCTs071200012). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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