| Abstrakt: |
A recent study conducted at Columbia University explored the effects of focused ultrasound-mediated blood-brain barrier (BBB) opening on brain macrophages. The researchers used single-cell sequencing to analyze the responses of microglia and central nervous system-associated macrophages (CAMs) in mice. They found that the treatment led to changes in the immune landscape, including the recruitment of CAMs and the proliferation of microglia. Additionally, the population of disease-associated microglia increased, accompanied by the upregulation of genes associated with gliogenesis and phagocytosis. The findings suggest that BBB opening through focused ultrasound could be a potential immunotherapy for neurodegenerative disorders. [Extracted from the article] |
