| Autor: |
Svabova, Tereza, Jelinkova, Anna, Gautam, Umesh Kumar |
| Předmět: |
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| Zdroj: |
Allergy; Nov2023, Vol. 78 Issue 11, p3038-3040, 3p |
| Abstrakt: |
This article discusses the role of gut microbiota and Lactobacillus species in maintaining the small intestine stem cell niche and reducing the severity of necrotizing enterocolitis (NEC). The microbiota plays a crucial role in mammalian development and physiology, and dysbiosis in infancy has been associated with various diseases. The study found that early-life gut microbiota exposure promotes the differentiation of intestinal stem cells into Paneth cells, which is important for small intestinal homeostasis. The researchers also demonstrated that transplantation of Lactobacillus rhamnosus corrected the impaired development of the mesenchymal niche and Paneth cell differentiation, partially rescuing the NEC-like phenotypes. However, further research is needed to fully understand the role of probiotic bacteria in preventing NEC and their potential as therapeutic agents. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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