| Abstrakt: |
Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive form of pulmonary hypertension. Although pulmonary hypertension is strongly associated with a high morbidity and mortality rate, this condition's prognosis and mortality rate are still unclear in Iran. This study aims to evaluate the correlation between the histopathologic findings in endarterectomy specimens of CTEPH patients and their mortality rate. Material and method: In this study, 65 patients from Masih Daneshvari Hospital, Tehran, Iran, who were diagnosed with CTEPH and underwent endarterectomy were studied from 2008 until 2018. A questionnaire, including two main sections, was filled out for each patient. One section contained basic characteristics of patients, such as age, sex, etc. In contrast, the other section had the histopathologic findings of endarterectomy specimens, such as the presence of media, intima, atherosclerosis, and blood clots. The mortality rate was obtained by following up with patients by calling them or their families on the phone. Ultimately, the data analysis was performed using SPSS software version 16 and the ANOVA method. Results: The patients' mean age was 46.2±13.09, consisting of 43.1% women and 56.9% men. Intima, blood clots, media, and atherosclerosis were seen in 89%, 86%, 67%, and 27% of the specimens, respectively. The mortality rate was 27%. Conclusion: The presence of the media of the vessel (muscular part of the vascular wall) in the histopathologic evaluation of samples of CTEPH patients who underwent endarterectomy was associated with an increased risk of mortality. [ABSTRACT FROM AUTHOR] |
