| Abstrakt: |
A recent study conducted by researchers at the Instituto Nacional de Enfermedades Respiratorias in Mexico City explored the expression and function of T-cell Immunoglobulin and Mucin Domain 3 (TIM-3) in human macrophages. The study found that TIM-3 expression was lower in M1 macrophages compared to M2 macrophages, and there were differential levels of soluble ADAM 10, an enzyme responsible for TIM-3 release, in the supernatants of M1 and M2 macrophages. Additionally, the study discovered that the TIM-3 intracellular tail may interact with lymphocyte-specific protein 1 (LSP-1), which is involved in cell motility and podosome formation. These findings contribute to our understanding of TIM-3 function in myeloid cells and may have implications for the development of immunotherapies with reduced immune-related adverse effects. [Extracted from the article] |
