Comparing the Effect of Nifedipine and Indomethacin on Pregnant Women with Idiopathic Preterm Labor.
| Autor: | L., Gholami, H., Zare, S., Afroughi, P. A., Eslamnik |
|---|---|
| Předmět: |
C-reactive protein
DRUG efficacy EOSINOPHILS LEUCOCYTES INDOMETHACIN PREGNANT women COMPARATIVE studies RANDOMIZED controlled trials NEUTROPHILS BLIND experiment DESCRIPTIVE statistics RESEARCH funding STATISTICAL sampling DATA analysis software PREMATURE labor NIFEDIPINE UTERINE contraction MONOCYTES EVALUATION |
| Zdroj: | Journal of Clinical Care & Skills; Spring2023, Vol. 4 Issue 2, p91-96, 6p |
| Abstrakt: | Aims In preterm delivery, uterine contractions begin prematurely and lead to the opening of the cervix. Nifedipine and Indomethacin drugs can help reduce contractions and delay childbirth. However, there are contradictions regarding their effect on preterm birth and inflammatory factors. This study aimed to compare the effect of nifedipine and indomethacin on uterine contractions, CRP, and white blood cells in pregnant women with idiopathic preterm labor. Materials & Methods This single-blind clinical trial was conducted on 68 eligible pregnant women hospitalized with premature labor pains in Imam Sajjad Yasuj Hospital in 2022 and randomly assigned to two groups. With tocography, the fixation contractions must have at least four contractions higher than 15mmHg. Before and 48h after interventions, the number and time of contractions, cervical dilatation, WBC, DIFF, and CRP tests were measured. Data were analyzed using SPSS 25 software. Findings Both interventions improved the number and time of contractions, CRP, and neutrophil. However, there were no significant differences in these variables between Nifedipine and Indomethacin groups. The study showed a statistically significant difference between groups in the number of eosinophils and monocytes after the intervention (p<0.05). Conclusion Nifedipine and Indomethacin improve the number and duration of contractions, CRP, monocytes, and neutrophils. Nifedipine causes more decrease in eosinophil levels than indomethacin. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|