Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas.

Autor: Herrgott, Grayson A., Snyder, James M., She, Ruicong, Malta, Tathiane M., Sabedot, Thais S., Lee, Ian Y., Pawloski, Jacob, Podolsky-Gondim, Guilherme G., Asmaro, Karam P., Zhang, Jiaqi, Cannella, Cara E., Nelson, Kevin, Thomas, Bartow, deCarvalho, Ana C., Hasselbach, Laura A., Tundo, Kelly M., Newaz, Rehnuma, Transou, Andrea, Morosini, Natalia, Francisco, Victor
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Zdroj: Nature Communications; 9/13/2023, Vol. 14 Issue 1, p1-19, 19p
Abstrakt: Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring. In this study, we analyze the DNA methylation levels in blood (serum and plasma) and tissue samples from 155 meningioma patients, compared to other central nervous system tumor and non-tumor entities. We discover DNA methylation markers unique to meningiomas and use artificial intelligence to create accurate and universal models for identifying and predicting meningioma recurrence, using either blood or tissue samples. Here we show that liquid biopsy is a potential noninvasive and reliable tool for diagnosing and predicting outcomes in meningioma patients. This approach can improve personalized management strategies for these patients. Recurrence of meningiomas is unpredictable by current methods based on surgically removed specimens, and identification of patients likely to recur could inform treatment strategy. Here, the authors analysed DNA methylation in liquid biopsy specimens from meningioma patients to help classify recurrence risk noninvasively even before surgery. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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