| Autor: |
Ambaryan, Alexander V., Kovalzon, Vladimir M., Ushakova, Nina A. |
| Předmět: |
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| Zdroj: |
Neuroscience & Behavioral Physiology; Jun2023, Vol. 53 Issue 5, p752-762, 11p |
| Abstrakt: |
Insects are a potential source of novel bioactive compounds with pharmaceutical applications. Our previous study revealed the presence of antioxidant system proteins in the aqueous extract of Ulomoides dermestoides Fairmaire 1893 larvae, which exhibited high antioxidant activity in vitro and improved cognitive and motor functions in aging mice. To determine whether the extract of Ulomoides dermestoides larvae can enhance motor control and cognitive performance in a neurotoxic model of the initial stage of Parkinson's disease, adult male C57Bl/6 mice (n = 10/group) were injected intraperitoneally with paraquat neurotoxin, which penetrates the blood–brain barrier and causes oxidative stress that destroys dopaminergic neurons of the substantia nigra (more detail about protocol treatment and motor and cognitive impairments typical for the mice model of PD can be found in our previous publication – Kovalzon et al. [19]. Two groups, E0.2 and E0.4, received either 0.2 or 0.4 mg/kg of daily oral doses of the aqueous extract of Ulomoides dermestoides larvae, respectively, for 1 week before and during neurotoxin administration. The effects were compared to neurotoxin-only (Ctox) and intact control (Cin) groups. Motor coordination and cognitive performance were assessed using the Rotarod, vertical pole, and object recognition tests. Neurotoxin administration significantly impaired motor and cognitive functions in Ctox. The E0.4 but not E0.2 treatment significantly attenuated the behavioral effects of the neurotoxin (up to the 90% of Cin values). Oral administration of the aqueous extract of Ulomoides dermestoides larvae can significantly counteract the impairments of motor skills and cognitive performance induced by the neurotoxic model of Parkinson's disease. The neuroprotective effect is likely to reflect the earlier established antioxidant properties of the extract. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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