The Association of the CYP19 and CYP17 Polymorphic Markers with Sporadic Breast Cancer.

Autor:	Artamonov, V. V., Lyubchenko, L. N., Shabanov, M. A., Babenko, O. V., Nemtsova, M. V., Zaletaev, D. V.
Předmět:	BREAST cancer CANCER CANCER patients GENETIC polymorphisms GENETIC research SEX hormones
Zdroj:	Molecular Biology; Nov/Dec2003, Vol. 37 Issue 6, p830-835, 6p
Abstrakt:	Polymorphic alleles of CYP17 and CYP19, which are involved in estrogen biosynthesis, were tested for association with breast cancer (BC). Microsatellite (TTTA)n and 3-bp deletion of CYP19 and single-nucleotide polymorphism T27C of CYP17 were analyzed in 123 BC patients and 119 healthy women. Of the six (TTTA)n alleles observed, allele (TTTA)8 proved to be associated with BC (11.8% vs. 6.3%, P = 0.04). Genotype A2/A2 of CYP17 was also associated with BC (32.5% vs. 20.2%, P = 0.04). Risk of BC was especially high in the presence of both factors (7.3% vs. 0%, P < 0.01). Allele (TTTA)8 and genotype A2/A2 were assumed to be risk factors of BC. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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