Comparative Survival Function in Patients with Positive Surgical Margins Following Laryngectomy.

Autor:	Özkul, Yılmaz, Ciğer, Ejder, Balcı, Mustafa Koray, Kılavuz, Ahmet Erdem, Bayrak, Feda, Songu, Murat, İşlek, Akif
Předmět:	SURGICAL margin LARYNGECTOMY PROGRESSION-free survival SURVIVAL analysis (Biometry)
Zdroj:	Indian Journal of Otolaryngology & Head & Neck Surgery; Sep2023, Vol. 75 Issue 3, p1625-1630, 6p
Abstrakt:	Aims: This study aims to make a comparative analysis of disease-free survival (DFS) and overall disease-specific survival (OS) in patients with laryngeal carcinoma. Materials and methods: The study was designed retrospectively. Sixteen patients with postoperative PSM and 30 with negative surgical margins (NSM) were included. Survival analysis and Long-Rank comparisons was performed for DFS and OS between groups. Results: PSM was a significant independent risk factor for loco-regional recurrence and disease-related mortality (p = 0.004, HR: 1.6, p = 0.002, HR: 3.2, respectively). DFS and OS were significantly longer in NSM group (p = 0.001 and 0.003, respectively). For PSM group, 2- and 5-year DFS rates were 57%; OS rates were 80% and 34% respectively. In NSM group, 2- and 5-year DFS rates were 96% and 83%; OS rates were found to be 96%. Conclusion: PSM had significant relation with poor prognosis. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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