Lipoprotein-associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease.

Autor: Lösche, W., Marshal, G. J., Krause, S., Kocher, T., Kinane, D. F.
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Zdroj: Journal of Clinical Periodontology; Jun2005, Vol. 32 Issue 6, p640-644, 5p
Abstrakt: Lösche W, Marshal GJ, Krause S, Kocher T, Kinane DF. Lipoprotein-associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease. J Clin Periodontol 2005; doi: 10.1111/j.1600-0521X.2005.00725.x.© Blackwell Munksgaard 2005.Periodontitis is believed to be an independent risk factor of cardiovascular disease (CVD) and to be associated with a moderate systemic inflammatory reaction and hyperlipidaemia. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that has been shown to be a risk factor of CVD and that is involved in the degradation of the phospholipid mediator platelet-activating factor (PAF), a potent mediator of inflammation.In the present study, we measured concentrations of plasma lipids and plasma activity of Lp-PLA2 in 32 patients (mean age 43±11 years) with moderate-to-severe periodontitis before and 3 months after local treatment.Periodontal therapy resulted in a significant reduction of local inflammation and tissue destruction as reflected in reduced pocket depths and reduced bleeding indices. Pre- and post-treatment plasma lipid levels were (median and range, mmol/l): total cholesterol (C) 5.01 (3.94–7.15) and 4.91 (3.32–8.01); low-density lipoprotein-cholesterol (LDL-C) 3.14 (2.40–4.84) and 2.96 (1.39–5.04); HDL-C 1.27 (0.73–2.17) and 1.25 (0.74–2.55); triglycerides 1.37 (0.48–5.11) and 1.14 (0.38–792). Using the Wilcoxon's rank test, neither parameter showed a significant change. In contrast to the lacking response of plasma lipids, we observed a significant reduction in the activity of Lp-PLA2. Local treatment lowered the enzyme activity by about 10% from 3.61±0.99 to 3.29±0.94 μmol/ml/h (mean±SD;p<0.001). The pre-treatment values of Lp-PLA2 and LDL-C significantly correlated with clinical parameters of inflammation and periodontal destruction.This study indicates that treatment of periodontitis significantly reduces the serum activity of Lp-PLA2, which is believed to be an independent cardiovascular risk factor. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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