| Autor: |
Lobato, Tiago Bertola, Gennari-Felipe, Matheus, Barbosa Pauferro, Janaína Ribeiro, Correa, Ilana Souza, Ferreira Santos, Beatriz, Belmiro Dias, Beatriz, de Oliveira Borges, João Carlos, dos Santos, Camila Soares, de Sousa Santos, Elvirah Samantha, Leite de Araújo, Maria Janaína, Araújo Ferreira, Liliane, Araujo Pereira, Sara, Afonso Serdan, Tamires Duarte, Levada-Pires, Adriana Cristina, Hatanaka, Elaine, Borges, Leandro, Cury-Boaventura, Maria Fernanda, Ramirez Vinolo, Marco Aurélio, Pithon-Curi, Tania Cristina, Masi, Laureane Nunes |
| Zdroj: |
Frontiers in Microbiology; 11/3/2022, Vol. 13, p1-18, 18p, 1 Black and White Photograph, 2 Diagrams |
| Abstrakt: |
Recent studies show that the metabolic characteristics of different leukocytes, such as, lymphocytes, neutrophils, and macrophages, undergo changes both in the face of infection with SARS-CoV-2 and in obesity and type 2 diabetes mellitus (DM2) condition. Thus, the objective of this review is to establish a correlation between the metabolic changes caused in leukocytes in DM2 and obesity that may favor a worse prognosis during SARS-Cov-2 infection. Chronic inflammation and hyperglycemia, specific and usual characteristics of obesity and DM2, contributes for the SARS-CoV-2 replication and metabolic disturbances in different leukocytes, favoring the proinflammatory response of these cells. Thus, obesity and DM2 are important risk factors for proinflammatory response and metabolic dysregulation that can favor the occurrence of the cytokine storm, implicated in the severity and high mortality risk of the COVID-19 in these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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