| Autor: |
Chun Kim, Gajendran, Nadesan, Mittrücker, Hans-Willi, Weiwad, Matthias, Young-Hwa Song, Hurwitz, Robert, Wilmanns, Matthias, Fischer, Gunter, Kaufmann, Stefan H. E., Fearon, Douglas T. |
| Předmět: |
|
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 3/29/2005, Vol. 102 Issue 13, p4830-4535, 6p |
| Abstrakt: |
Anthrax caused by Bacillus anthracis represents a major bioterroristic threat. B. anthracis produces lethal toxin (LeTx), a combination of lethal factor (LF) and protective antigen that plays a major role in anthrax pathogenesis. We demonstrate that human neutrophil a-defensins are potent inhibitors of LF. The inhibition of IF by human neutrophil protein (HNP-1) was noncompetitive. HNP-1 inhibited cleavage of a mitogen-activated protein kinase kinase and restored impaired mitogen-activated protein kinase signaling in LeTx-treated macrophages. HNP-1 rescued murine macrophages from B. anthracis-induced cytotoxicity, and in vivo treatment with HNP-1-3 protected mice against the fatal consequences of LeTx. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
