| Autor: |
Mazières, Bernard, Rouanet, Stéphanie, Velicy, Joanne, Scarsi, Claudia, Reiner, Valentina |
| Předmět: |
|
| Zdroj: |
American Journal of Sports Medicine; Apr2005, Vol. 33 Issue 4, p515-523, 9p |
| Abstrakt: |
Background: Topical nonsteroidal anti-inflammatory drugs offer the advantage of enhanced drug delivery to local affected tis- sues with low plasma levels and an expected reduced incidence of systemic adverse events (mainly peptic ulcer disease and gastrointestinal hemorrhage). Hypothesis: To test the efficacy and tolerability of a 100-mg patch of ketoprofen applied once a day. Study Design: Randomized controlled clinical trial; Level of evidence, 1. Methods: The 2-week trial included patients suffering painful (spontaneous pain ≥50 mm on a 0- to 100-mm visual analog scale), benign (grade 1 or II), recent (<2 days) ankle sprains as a model of general traumatic soft tissue injuries. The primary efficacy criterion was spontaneous pain change after 7 days of treatment in the intention-to-treat population. One hundred sixty-three patients were randomized (ketoprofen, 81; placebo, 82). Results: After 1 week of treatment, the decrease in spontaneous pain was -50 ±20 mm for ketoprofen and -38 ± 24 mm for the placebo, showing a statistically significant intergroup difference (P = .0007). The majority of the secondary criteria were also statistically significant in favor of the ketoprofen patch. Tolerance was good in both groups, adverse events being mostly local. Conclusion: This trial suggested that a 7-day course of treatment with a ketoprofen patch is useful in benign ankle sprain, with- out revealing unexpected adverse events. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
