The association between drug pricing and drug shortage in Saudi Arabia: a retrospective database analysis.

Autor: Alowairdhi, Mohammad A., Alhussain, Fatimah H., Alomran, Maha I., Almadani, Ohoud A., Alkhammash, Norah A., Alyabes, Shayma F., Alharbi, Sultan A., Almudaiheem, Esraa A., Alhaider, Reem A., Alhassan, Sara A., Almuallem, Zainab A., Algain, Nuha, Alshehri, Abdulaziz O., Alshammari, Thamir M., Althunian, Turki A.
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Zdroj: Journal of Pharmaceutical Policy & Practice; 7/18/2023, Vol. 16 Issue 1, p1-6, 6p
Abstrakt: Background: Previous studies have suggested that drug pricing could contribute to drug shortages; however, there is limited quantitative assessment of this potential causal association. This retrospective database analysis aimed to investigate the association between drug prices and drug shortage incidents in Saudi Arabia. Methods: This was a retrospective database analysis study. Drugs with shortage notifications sent to the Saudi Food and Drug Authority (SFDA) between January 2017 and December 2020 were included. Each drug's foreign-to-Saudi price ratio (FTSPR) was calculated by dividing the mean international price by the Saudi price. Drugs were categorized into three groups based on their FTSPR: Group 1 (FTSPR > 1), Group 2 (FTSPR = 1), and Group 3 (FTSPR < 1). The primary outcome was the ratio of mean counts (mCR) between the three groups, with Group 3 serving as the control group. The analysis was adjusted for the measured confounders using a negative binomial regression model. Results: A total of 900 drugs were included in the study, with 348 in Group 1, 345 in Group 2, and 209 in Group 3. The mean count in Group 1 was higher compared to Group 3 (mCR: 1.88; 95% confidence interval [CI] 1.24 to 2.83), while the mean counts between Group 2 and Group 3 were comparable (mCR: 1.39; 95% CI 0.92 to 2.09). Conclusions: Our findings indicate an association between drug shortage incidents and higher prices of drugs outside Saudi Arabia. Further studies are needed to explore this causal relationship in different contexts. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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