Confirmation of PSMA expression measured on [68Ga]Ga-PSMA PET/CT by immunohistochemistry in prostate adenocarcinoma.
| Autor: | Sengoz, Tarik, Turk, Nilay Sen, Ozlulerden, Yusuf, Celen, Sinan, Gultekin, Aziz, Yaylali, Olga, Yuksel, Dogangun |
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| Předmět: |
ADENOCARCINOMA
PROSTATECTOMY STAINS & staining (Microscopy) CONFIDENCE intervals IMMUNOHISTOCHEMISTRY POSITRON emission tomography computed tomography RETROSPECTIVE studies REGRESSION analysis PROSTATE DESCRIPTIVE statistics COMPUTED tomography PROSTATE-specific antigen STATISTICAL correlation PROSTATE tumors TUMOR grading |
| Zdroj: | Nuclear Medicine Review; 2023, Vol. 26, p68-73, 6p |
| Abstrakt: | Background: Our aim is to determine the accuracy of [68Ga]Ga-PSMA PET/CT in showing PSMA expression in primary prostate cancer and to investigate the relationship between SUVmax and immunohistochemical PSMA expression, Gleason score, and PSA value. Material and methods: We retrospectively analyzed 66 male patients who were diagnosed with primary prostate adenocarcinoma, underwent pre-treatment [68Ga]Ga-PSMA PET/CT examination for staging, and performed radical prostatectomy between March 2018-August 2020. Immunohistochemical staining was applied to the radical prostatectomy specimens of all patients to detect PSMA expression. The results were evaluated as an immunoreactive score (IRS) and a modified IRS was obtained. Gleason score groups and prostate-specific antigen (PSA) serum values of the patients were obtained from the patient files. Results: The high SUVmax of primary prostate tumors was significantly correlated with a high modified IRS score (score 2; 3), high PSA value, high Gleason score, and metastasis. In correlation analysis, a positive correlation was found between SUVmax and PSA value and modified IRS score (r = 0.69, p = 0.001; r = 0.39, p = 0.001). In addition, there was a statistically significant weak correlation between PSA serum concentration and modified IRS scores (r = 0.267; p = 0.03). In regression analysis, the percentage of positive cells had a statistically significant and increasing effect on SUVmax (p = 0.031; std beta = 0.268; 95% CI = 0.231-4.596). Conclusions: In prostate adenocarcinoma, SUVmax of the primary tumor in [68Ga]Ga-PSMA PET/CT correlates with immunohistochemical PSMA expression. In addition, high SUVmax is associated with markers of poor prognoses, such as high PSMA expression, PSA value, and Gleason score. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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