Combined single‐cell and spatially‐resolved mapping of lymph node ecosystems reveals principles of lymphoma tissue organization.

Autor: Czernilofsky, F., Mathioudaki, A., Jopp‐Saile, L., Lutz, R., Vonficht, D., Baertsch, M., Vohringer, H., Roider, T., Ordoñez‐Rueda, D., Pabst, C., Huber, W., Trumpp, A., Müller‐Tidow, C. Carsten, Zaugg, J., Hübschmann, D., Haas, S., Dietrich, S.
Předmět:
Zdroj: Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p263-264, 2p
Abstrakt: To determine the molecular programs underlying loss of tissue organization, we employed holistic single-cell transcriptomic mapping of the lymph node ecosystem, covering major lymph node resident cell types, including rare mesenchymal and endothelial populations. B Introduction: b Non-Hodgkin lymphoma (NHL) NHL arise in lymph nodes whose normal architecture is variably altered by different NHL subtypes. Combined single-cell and spatially-resolved mapping of lymph node ecosystems reveals principles of lymphoma tissue organization. [Extracted from the article]
Databáze: Complementary Index