| Autor: |
Isa, H. I., Saleh, A., Shittu, M., Suleiman, M. M., Ambali, S. F. |
| Předmět: |
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| Zdroj: |
Savannah Veterinary Journal; 2022, Vol. 5 Issue 2, p25-33, 9p |
| Abstrakt: |
Introduction: Snake envenomation is a significant health crisis in developing countries. The victims in rural areas utilize traditional herbal remedies. Plants including Commiphora africana (C. africana) are traditionally believed to have antivenin property. The study was to evaluate the antivenom effect of C. africana. Methods: Male Swiss Albino mice (n = 20) were haphazardly allotted into 4 equal groups. Group I (control) was injected intraperitoneally with lethal dose-99 (LD99, 9.7 mg/kg) of Naja nigricollis venom. Groups II, III and IV were pre-treated with crude methanol extract (CME) of C. africana at 200, 300 and 400 mg/kg, respectively and 15 minutes were later administered the venom (LD99). Post-treatment with the extract (15 minutes after venom administration) was similarly evaluated. n-Butanol fraction (nBF) was also tested. Toxic signs and death time were documented over 24 hour period. Results: The CME and nBF were relatively acutely safe with LD50 of 3807.89 and >5000 mg/kg, respectively. Venom lethality assay gave LD99 of 9.7 mg/kg. Mice pre-treated with CME at 200, 300 and 400 mg/kg before administration of LD99 of the venom survived significantly (p<0.05) longer. Post-treatment at 400 mg/kg, significantly (p<0.05) increased the survival time. For nBF, pre-treatment with 400 and 500 mg/kg, significantly (p<0.05) increased the survival time. Mice post-treated with 500 mg/kg nBF, survived to 500.00 ± 98.07 minutes which was significant (p<0.05). Significance: The extract and fraction of C. africana showed dose-dependent mitigating effect against N. nigricollis envenomation in mice. The plant may be developed further as an antidote for snakebites. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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