Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection.

Autor: Shabir, Sadia, Spencer, Caleb T, Tabassum, Arooj, Chandra, Arjun, Sayeh, Wasef, Safi, Fadi, Ud din, Shahab
Zdroj: Journal of Investigative Medicine High Impact Case Reports; 1/1/2023, Vol. 11, p1-3, 3p
Abstrakt: This is a case report of a previously healthy female patient with complement-mediated thrombotic microangiopathy (TMA) caused by a systemic cytomegalovirus infection that was successfully treated with plasmapheresis, steroids, and parenteral valganciclovir. Complement-mediated TMA is the result of various genetic mutations leading to complement abnormalities with overactivation of alternate complement pathway in response to a triggering infection. She also had splenic rupture without splenomegaly and was managed successfully without splenectomy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index