| Autor: |
Hesari, Kambiz Kamyab, Ramezanizoorab, Negar, Ramezani, Mazaher, Sadeghi, Masoud, Rezaei, Mansour, Khazaei, Sedigheh |
| Předmět: |
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| Zdroj: |
Journal of Pakistan Association of Dermatologists; Oct-Dec2022, Vol. 32 Issue 4, p676-682, 7p |
| Abstrakt: |
Objective The purpose of this study was to evaluate the immunohistochemical expression of Ki-67 marker in Mycosis Fungoides (MF) and Lichen Planus (LP) lesions. Methods This cross-sectional analytical study included patients undergoing skin biopsy with their first clinical and pathologic diagnosis of MF and cutaneous LP by Ki-67 immunohistochemistry (IHC). Sixty-two patients with cutaneous LP and MF were studied in two groups of 39 and 23 patients, respectively. Linear regression was used for the possible correlation between age and Ki-67 index (%) in both LP and MF patients. Results The results of this study found that Ki-67 was expressed in 100% of both MF and LP lesions, and no significant correlation was found between Ki-67 and either of the two types of diseases (p=0.606). The results of this study also showed that expression of Ki-67 marker was more than 25% in both types of diseases in 70% of the population, which seems not to be directly related to malignancy. Conclusion IHC with proliferative marker Ki-67 is not a valuable technique for differentiating cutaneous LP from MF lesions alone. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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