| Autor: |
Morales, Angelica M., Gilbert, Sydney, Hart, Elijah, Jones, Scott A., Boyd, Stephen J., Mitchell, Suzanne H., Nagel, Bonnie J. |
| Předmět: |
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| Zdroj: |
Alcohol, Clinical & Experimental Research; Apr2023, Vol. 47 Issue 4, p659-667, 9p |
| Abstrakt: |
Background: Studies in animals and humans suggest that greater levels of sensation seeking and alcohol use are related to individual differences in drug‐induced dopamine release. However, it remains unclear whether drug‐induced alterations in the functional synchrony between mesostriatal regions are related to sensation seeking and alcohol use. Methods: In this within‐subject masked‐design study, 21‐year‐old participants (n = 34) underwent functional magnetic resonance imaging to measure ventral tegmental area (VTA) resting‐state functional connectivity to the striatum after receiving alcohol (target blood alcohol concentration 0.08 g/dL) or placebo. Participants also completed the UPPS‐P Impulsive Behavior Scale to assess sensation seeking, the Young Adult Alcohol Consequences Questionnaire, and self‐reported patterns of alcohol and drug use. Results: Voxel‐wise analyses within the striatum demonstrated that during the alcohol condition (compared with placebo) young adults had less connectivity between the VTA and bilateral caudate (p < 0.05 corrected). However, young adults exhibiting smaller alcohol‐induced decreases or increases in VTA‐left caudate connectivity reported greater sensation seeking. Conclusion: These findings provide novel information about how acute alcohol impacts resting‐state connectivity, an effect that may be driven by the complex pre and postsynaptic effects of alcohol on various neurotransmitters including dopamine. Further, alcohol‐induced differences in VTA connectivity represent a plausible mechanistic substrate underlying sensation seeking. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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