| Autor: |
Kanayama, Shuji, Himeno, Seiichi, Kurokawa, Masanori, Shinomura, Yasuhisa, Kuroshima, Toshio, Okuno, Masaru, Tsuji, Kagetoshi, Higashimoto, Yoshifumi, Ikei, Nobuhiro, Hashimura, Etsuro, Tateishi, Kayoko, Hamaoka, Toshiyuki, Tarui, Seiichiro |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Jul1985, Vol. 80 Issue 7, p557-560, 4p, 1 Chart, 3 Graphs |
| Abstrakt: |
For exploration on the elimination of cholecystokinin from the circulation, the disappearance half-time of cholecystokinin-octapeptide was estimated with cholecystokinin specific radioimmunoassay in normal subjects and patients with chronic renal failure and with hepatic cirrhosis. With a brief infusion of 30.4 ng/kg of cholecystokinin-octapeptide for 2 min, plasma cholecystokinin level rose from 16.1 ± 3.6 pg/ml (mean ± SE) to 216.5 ± 6.1 pg/ml at 3 min after starting infusion, and decreased rapidly in a single exponential fashion for 10 min in hepatic cirrhosis. The disappearance half-time of cholecystokinin-octapeptide in patients with hepatic cirrhosis was 2.45 ± 0.07 min, and it was significantly longer than that in normal subjects (1.30 ± 0.07) or patients with chronic renal failure (1.70 ± 0.11). These findings suggest that the liver plays a major role in cholecystokinin-octapeptide elimination in humans. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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